Lane 1: Hela cell lysate
Lane 2: HepG2 cell lysate
Rabbit polyclonal primary
GLUD1 Antibody (ER1902-85)
Synthetic peptide within human glud1 aa 120-160.
Hela cell lysate, HepG2 cell lysate, rat kidney tissue, human liver tissue, human liver carcinoma tissue, human colon carcinoma tissue, human breast carcinoma tissue, mouse liver tissue, SW620.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified.
AI118167 antibody; DHE3_HUMAN antibody; EC 22.214.171.124 antibody; GDH 1 antibody; GDH antibody; Gdh-X antibody; GDH1 antibody; GLUD antibody; Glud1 antibody; Glud1a antibody; Glud1b antibody; Gludl antibody; Glutamate dehydrogenase (NAD(P)+) antibody; Glutamate dehydrogenase 1 antibody; Glutamate dehydrogenase 1 mitochondrial antibody; Glutamate dehydrogenase 1a antibody; Glutamate dehydrogenase 1b antibody; Memory-related gene 2 protein antibody; MGC127177 antibody; MGC132003 antibody; MGC80801 antibody; MGC93608 antibody; mitochondrial antibody; MRG-2 antibody
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
ADP-ribosylated by SIRT4, leading to inactivate glutamate dehydrogenase activity (By similarity). Stoichiometry shows that ADP-ribosylation occurs in one subunit per catalytically active homohexamer.
This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X.