Rabbit polyclonal primary
Foxk2 Antibody (ER2001-47)
Recombinant protein within mouse foxk2 aa 1-350.
293 cell lysates, mouse lung tissue, mouse colon tissue, mouse brain tissue, SHSY5Y.
Store at +4Á¾ after thawing. Aliquot store at -20Á¾. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein affinity purified.
Cellular transcription factor ILF 1 antibody; Cellular transcription factor ILF-1 antibody; Cellular transcription factor ILF1 antibody; Forkhead box K2 antibody; Forkhead box protein K2 antibody; FOX K1 antibody; FOX K2 antibody; FOXK 1 antibody; FOXK 2 antibody; FOXK1 antibody; foxk2 antibody; FOXK2_HUMAN antibody; ILF 1 antibody; ILF antibody; Interleukin enhancer binding factor 1 antibody; Interleukin enhancer-binding factor 1 antibody
Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy . Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context . Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen . Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 . Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate . Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins . In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription (By similarity). Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRT[G/T]NB-3' sequence (By similarity). Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (By similarity). Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus (By similarity).