Rabbit polyclonal primary
Fibulin 5 Antibody (ER1802-95)
Recombinant protein within human fibulin 5 210-360 aa.
Human skin tissue, JAR, SiHa, SKOV-3, rat testis tissue, mouse ovary tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein affinity purified.
FIBL-5, Dance, UP50, FBLN5, DANCE
Belongs to the fibulin family.
Expressed in skin fibroblasts (at protein level)(PubMed:17035250). Expressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and placenta. Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes.
Secreted. Secreted, extracellular space, extracellular matrix. Note=co-localizes with ELN in elastic fibers.
Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN.