UNIPROT #

Q804Q5

PROTEIN NAME

FEZF2

SYNONYMS

Fez antibody; FEZ family zinc finger protein 2 antibody; FEZF 2 antibody; FEZF2 antibody; FEZL antibody; Forebrain embryonic zinc finger like protein 2 antibody; TOF antibody; ZFP 312 antibody; ZFP312 antibody; Zinc finger FEZL antibody; Zinc finger protein 312 antibody; Zinc finger protein FEZ like antibody; ZNF 312 antibody

SEQUENCE SIMILARITIES

Belongs to the krueppel C2H2-type zinc-finger protein family.

TISSUE SPECIFICITY

No expression seen in DA or 5HT neurons.

DEVELOPMENTAL STAGE

Expressed in the most anterior part of the prospective neural plate along the rostral-caudal axis. At the tail bud stage, expressed in the prospective forebrain region. From 15-somite to 24 hours post-fertilization (hpf), expression is mostly confined to the telencephalon and the anterior-ventral region of diencephalon Expression is restricted to ectoderm at 80% epiboly stage. From 15-somite to 24 hpf, expression is mostly confined to the telencephalon and the anterior-ventral region of diencephalon.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

ZNF312, also known as Fezf2 or Fez-like, is a zinc finger protein that acts as a transcriptional repressor during the development of corticospinal motor neurons and other subcerebral projection neurons. ZNF312 is expressed by early progenitor cells in the ventricular zone. It regulates the fate choice of subcortical projection neurons in the developing cerebral cortex. This protein is expressed in the developing cortical plate during early embryonic development. During late embryonic development and early postnatal development, ZNF312 expression disappears from the cortical progenitors and becomes restricted to the subplate nad the prospective layer V and VI pyramidal neurons.