Positive control:
Lane 1: Human brain tissue lysate
Lane 2: HepG2 cell lysate
Applications
-
WB
REACTIVITY
-
Human
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
FCGRT Antibody (ER2001-44)
Immunogen
Synthetic peptide within human fcgrt aa 20-70.
Host
Rabbit
Positive Control
Human brain tissue lysate, HepG2 cell lysate.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4Á¾ after thawing. Aliquot store at -20Á¾. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Protein A affinity purified.
MOLECULAR WEIGHT
Predicted band size: 40 kDa.
Isotype
IgG
APPLICATION DILUTION
-
WB
-
1:500-1:1,000
TARGET
UNIPROT #
PROTEIN NAME
FCGRT
SYNONYMS
Alpha chain antibody; Fc fragment of IgG, receptor transporter, alpha antibody; FCGRN_HUMAN antibody; FCGRT antibody; FcRn alpha chain antibody; FcRn antibody; FCRN, alpha chain antibody; IgG Fc fragment receptor transporter alpha chain antibody; IgG Gc receptor antibody; IgG receptor FcRn large subunit p51 antibody; IgG receptor FcRn large subunit p51 precursor antibody; Immunoglobulin receptor, intestinal, heavy chain antibody; Neonatal Fc receptor antibody
SUBCELLULAR LOCATION
Cell membrane, Endosome, Membrane.
FUNCTION
Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk . IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation . In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB .