Lane 1: Human brain tissue lysate
Lane 2: HepG2 cell lysate
Rabbit polyclonal primary
FCGRT Antibody (ER2001-44)
Synthetic peptide within human fcgrt aa 20-70.
Human brain tissue lysate, HepG2 cell lysate.
Store at +4Á¾ after thawing. Aliquot store at -20Á¾. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Predicted band size: 40 kDa.
IgG receptor FcRn large subunit p51 FcRn IgG Fc fragment receptor transporter alpha chain Neonatal Fc receptor FCGRT
Cell membrane, Endosome, Membrane.
Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk . IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation . In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB .