Rabbit polyclonal primary
FBXL18 Rabbit Polyclonal Antibody (ER1802-89)
Synthetic peptide within human fbxl18 aa 756-805 / 805.
PC-3M, rat liver tissue, human liver tissue, mouse liver tissue, A549.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified.
F box and leucine rich repeat protein 18 antibody; F box/LRR repeat protein 18 antibody; FBL18 antibody; FBXL 18 antibody; FLJ10776 antibody; FLJ11467 antibody; FLJ26934 antibody; FLJ38075 antibody; FLJ41541 antibody
FBL18 (F-box and leucine-rich repeat protein 18), also known as FBXL18, is an 805 amino acid protein that contains an F-box near its N-terminus, followed by several leucine-rich repeats and a transmembrane domain at the C-terminus. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins and cyclin-dependent kinase inhibitors (CDKNs), for degradation by the proteasome after ubiquitination. FBL18 directly interacts with SKP1A p19 and CUL-1, forming a substrate-recognition component of the SCF-type E3 ubiquitin ligase complex. Four isoforms of FBL18 exist due to alternative splicing.