Applications
-
IHC-P
-
FC
REACTIVITY
-
Human
-
Mouse
-
Rat
SPECIFICATIONS
Product Type
Mouse monoclonal primary
Product Name
Dynamin 1 Monoclonal Antibody (EM1901-43)
Immunogen
Recombinant protein within human dynamin 1 aa 500-800.
Host
Mouse
Positive Control
Rat brain tissue, mouse brain tissue, A549.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
A1B1
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
2 ug/ul
PURIFICATION
Protein A affinity purified.
MOLECULAR WEIGHT
97 kDa
Isotype
IgM
APPLICATION DILUTION
-
IHC-P:1:50-1:200
-
FC:1:50-1:100
TARGET
UNIPROT #
PROTEIN NAME
Dynamin 1
SYNONYMS
B dynamin antibody; D100 antibody; DNM 1 antibody; DNM antibody; DNM1 antibody; DYN1_HUMAN antibody; Dynamin antibody; Dynamin-1 antibody; Dynamin1 antibody
SEQUENCE SIMILARITIES
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
SUBCELLULAR LOCATION
Cytoskeleton, cytoplasm.
FUNCTION
This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described.