Rabbit polyclonal primary
Cytokeratin 8 Antibody (ER1803-87)
Recombinant protein within human cytokeratin 8 aa 380-500.
K562, LOVO, human liver tissue, human breast cancer tissue, human kidney tissue, MCF-7.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein affinity purified.
Keratin, type II cytoskeletal 8
CK-8, K8, KRT8, CYK8.
Belongs to the intermediate filament family.
Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.; O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation.; O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
Cytoplasm. Nucleus, nucleoplasm. Nucleus matrix.
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.