Mouse monoclonal primary
Cytokeratin 14 Monoclonal Antibody (EM1901-32)
Synthetic peptide within n terminal human cytokeratin 14.
A431 cell lysates, human skin tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein G purified.
Keratin, type I cytoskeletal 14
Keratin, type I cytoskeletal 14 Cytokeratin-14 CK-14 Keratin-14 K14 KRT14
Belongs to the intermediate filament family.
Expressed in the corneal epithelium (at protein level). Detected in the basal layer, lowered within the more apically located layers specifically in the stratum spinosum, stratum granulosum but is not detected in stratum corneum. Strongly expressed in the outer root sheath of anagen follicles but not in the germinative matrix, inner root sheath or hair. Found in keratinocytes surrounding the club hair during telogen.
A disulfide bond is formed between rather than within filaments and promotes the formation of a keratin filament cage around the nucleus.; Ubiquitinated by the BCR(KLHL24) E3 ubiquitin ligase complex.
Cytoplasm. Nucleus. Note=Expressed in both as a filamentous pattern.
The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.