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PRODUCT CODE: em1701-36

CTHRC1 Monoclonal Antibody (EM1701-36)

Applications

  • WB

  • IHC-P

REACTIVITY

  • Human

  • Mouse

  • Rat

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Western blot analysis of CTHRC1 on CTHRC1 recombinant protein using anti-CTHRC1 antibody at 1/500 dilution.
  • Western blot analysis of CTHRC1 on CTHRC1 recombinant protein using anti-CTHRC1 antibody at 1/500 dilution.
  • Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-CTHRC1 antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-CTHRC1 antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded rat large intestine tissue using anti-CTHRC1 antibody. Counter stained with hematoxylin.
Western blot analysis of CTHRC1 on CTHRC1 recombinant protein using anti-CTHRC1 antibody at 1/500 dilution.

Applications

  • WB

  • IHC-P

REACTIVITY

  • Human

  • Mouse

  • Rat

SPECIFICATIONS

Product Type

Mouse monoclonal primary

Product Name

CTHRC1 Monoclonal Antibody (EM1701-36)

Immunogen

Recombinant protein

Host

Mouse

Positive Control

CTHRC1 recombinant protein, rat large intestine tissue, human kidney tissue, human placenta tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

5H1

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

2 ug/ul

PURIFICATION

Protein A purified.

MOLECULAR WEIGHT

26 kDa

Isotype

IgG1

APPLICATION DILUTION

  • WB

  • 1:500-1:1,000

  • IHC-P

  • 1:50-1:200

TARGET

UNIPROT #

Q96CG8

PROTEIN NAME

Collagen triple helix repeat-containing protein 1

GENE NAME

CTHRC1

SYNONYMS

CTHRC1, UNQ762/PRO1550

TISSUE SPECIFICITY

Isoform 1 is expressed in calcified atherosclerotic plaque and chondrocyte-like cells.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated.

SUBCELLULAR LOCATION

Secreted, extracellular space, extracellular matrix.

FUNCTION

May act as a negative regulator of collagen matrix deposition.

CITATIONS

  • Ma, Ming-Ze et al.

    CTHRC1 acts as a prognostic factor and promotes invasiveness of gastrointestinal stromal tumors by activating Wnt/PCP-Rho signaling. | Neoplasia (New York, N.Y.) [2014]

  • Yang, Xiao-Mei et al.

    CTHRC1 promotes human colorectal cancer cell proliferation and invasiveness by activating Wnt/PCP signaling. | International Journal of Clinical and Experimental Pathology [2015]

  • Li, Jun et al.

    Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-�_ signaling. | EbioMedicine [2019]