Lane 1: 293T cell lysate, untreated
Lane 2: NIH/3T3 cell lysate, untreated
Rabbit polyclonal primary
COX1/Cyclooxygenase 1 Antibody (0807-3)
Synthetic peptide corresponding to c-terminal of human cox1/cyclooxygenase 1.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 25% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified.
Prostaglandin G/H synthase 1
COX-1,PGH synthase 1,PGHS-1,PHS 1
Belongs to the prostaglandin G/H synthase family.
Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.