Lane 1: Hela cell lysate
Lane 2: SKBR-3 cell lysate
Rabbit polyclonal primary
Clusterin Antibody (ER2001-58)
Synthetic peptide within human clusterin aa350-449.
Hela cell lysate, SKBR-3 cell lysate, human tonsil tissue, human pancreas tissue, A549.
Store at +4Á¾ after thawing. Aliquot store at -20Á¾. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified.
Predicted band size: 52 kDa.
Clusterin,Aging-associated gene 4 protein,Apolipoprotein J,Apo-J,Complement cytolysis inhibitor,CLI,Complement-associated protein SP-40,40,Ku70-binding protein 1 NA1/NA2,Sulfated glycoprotein 2,Testosterone-repressed prostate message 2,TRPM-2,Clusterin beta chain ApoJalpha Complement cytolysis inhibitor a chain Clusterin alpha chain ApoJbeta Complement cytolysis inhibitor b chain SGP-2 CLU
Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Microsome, Mitochondrion, Nucleus, Secreted.
Detected in blood plasma, cerebrospinal fluid, milk, seminal plasma and colon mucosa. Detected in the germinal center of colon lymphoid nodules and in colon parasympathetic ganglia of the Auerbach plexus (at protein level). Ubiquitous. Detected in brain, testis, ovary, liver and pancreas, and at lower levels in kidney, heart, spleen and lung.Clusterin (apolipoprotein J) is a 75 - 80 kDa disulfide-linked heterodimeric protein associated with the clearance of cellular debris and apoptosis.In humans, clusterin is encoded by the CLU gene on chromosome CLU is a molecular chaperone responsible for aiding protein folding of secreted proteins, and its three isoforms have been differentially implicated in pro- or antiapoptotic processes. Through this function, CLU is involved in many diseases related to oxidative stress, including neurodegenerative diseases, cancers, inflammatory diseases, and aging.