PRODUCT CODE: 1003-9

CD271 Antibody (1003-9)

Applications

  • WB

  • ICC

  • IHC-P

  • FC

REACTIVITY

  • Mouse

  • Rat

Western blot analysis on D3 (A) and PC12 (B) using anti-CD271 polyclonal antibody.
  • Western blot analysis on D3 (A) and PC12 (B) using anti-CD271 polyclonal antibody.
Western blot analysis on D3 (A) and PC12 (B) using anti-CD271 polyclonal antibody.

Applications

  • WB

  • ICC

  • IHC-P

  • FC

REACTIVITY

  • Mouse

  • Rat

SPECIFICATIONS

Product Type

Rabbit polyclonal primary

Product Name

CD271 Antibody (1003-9)

Immunogen

Peptide

Host

Rabbit

Positive Control

PC12, D3

Conjugation

Unconjugated

Clonality

Polyclonal

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Immunogen affinity purified

MOLECULAR WEIGHT

50kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:2,000~1:5,000

TARGET

UNIPROT #

PROTEIN NAME

Tumor necrosis factor receptor superfamily member 16

GENE NAME

Ngfr

SYNONYMS

NGF receptor

TISSUE SPECIFICITY

Detected in Schwann cells. Detected in embryonic brain, in hippocampus neurons (at protein level). Detected in brain and spinal cord.

DEVELOPMENTAL STAGE

Detected in embryonic large blood vessels at 11.5 dpc.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated. O-glycosylated.; Phosphorylated on serine residues.

SUBCELLULAR LOCATION

Cell membrane; Single-pass type I membrane protein. Cell projection, growth cone. Cell projection, dendritic spine.

FUNCTION

Low affinity neurotrophin receptor which can bind to mature NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF (proNGF), BDNF (proBDNF) and NTF3 (proNT3) with high affinity, and has much lower affinity for mature NGF and BDNF. Plays an important role in differentiation and survival of specific neuronal populations during development. Can mediate cell survival as well as cell death of neural cells. The heterodimeric receptor formed with SORCS2 plays a role in proBDNF-dependent synaptic plasticity, in hippocampal long term depression (LTD) and long term potentiation (LTP). Plays a role in the inactivation of RHOA (By similarity). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.; (Microbial infection) Cell surface receptor for rabies virus glycoprotein Gs.; [Isoform 2]: Does not bind NGF, BDNF, NTF3, and NTF4.