Lane 1: Mouse kidney tissue lysate
Lane 2: Rat brain tissue lysate
Lane 3: Hela cell lysate
Rabbit polyclonal primary
CBARA1 Antibody (ER1803-99)
Recombinant protein within human cbara1 aa 14-154.
Mouse kidney tissue, rat brain tissue, Hela.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein affinity purified.
Calcium uptake protein 1, mitochondrial
ara CALC, MICU1, CALC, CBARA1
Belongs to the MICU1 family. MICU1 subfamily.
Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells.
Mitochondrion inner membrane; Single-pass membrane protein.
Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.