Lane 1: SK-BR-3 cell lysate
Lane 2: MCF-7 cell lysate
Mouse monoclonal primary
Cathepsin D Monoclonal Antibody (EM1901-03)
Recombinant protein within human cathepsin d aa 1-432.
SK-BR-3, MCF-7, human liver tissue, human liver cancer tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein affinity purified.
Belongs to the peptidase A1 family.
Expressed in the aorta extracellular space (at protein level). Expressed in liver (at protein level).
N- and O-glycosylated.; Undergoes proteolytic cleavage and activation by ADAM30.; As well as the major heavy chain which starts at Leu-169, 2 minor forms starting at Gly-170 and Gly-171 have been identified. An additional form starting at Ala-168 has also been identified.
Lysosome. Melanosome. Secreted, extracellular space. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix.
Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.