Positive control:
Lane 1: Siha cell lysate
Lane 2: A549 cell lysate
Applications
-
WB
-
IHC-P
-
FC
REACTIVITY
-
Human
-
Mouse
-
Rat
SPECIFICATIONS
Product Type
Mouse monoclonal primary
Product Name
CASK Monoclonal Antibody (EM1902-08)
Immunogen
Recombinant protein within human cask aa 320-550.
Host
Mouse
Positive Control
Siha cell lysate, A549 cell lysate, rat large intestine tissue, human prostate cancer tissue, mouse brain tissue, SW620.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
A1C7
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
2 ug/ul
PURIFICATION
Protein A purified
MOLECULAR WEIGHT
105 kDa
Isotype
IgG1
APPLICATION DILUTION
-
WB:1:500-1:1000
-
IHC-P:1:50-1:200
-
FC:1:50-1:100
TARGET
UNIPROT #
PROTEIN NAME
CASK
SYNONYMS
CAGH39 antibody; Caki antibody; Calcium/calmodulin dependent serine protein kinase antibody; Calcium/calmodulin dependent serine protein kinase (MAGUK family) antibody; Calcium/calmodulin dependent serine protein kinase membrane associated guanylate kinase antibody; Calcium/calmodulin-dependent serine protein kinase antibody; CAMGUK antibody; CAMGUK protein antibody; CAMGUK, drosophila, homolog of antibody; casK antibody; CMG antibody; CSKP_HUMAN antibody; DXPri1 antibody; DXRib1 antibody; FGS4 antibody; FLJ22219 antibody; FLJ31914 antibody; hCASK antibody; LIN 2 antibody; Lin 2 homolog antibody; LIN2 antibody; Lin2 homolog antibody; MICPCH antibody; MRXSNA antibody; Pals3 antibody; Peripheral plasma membrane protein CASK antibody; Protein lin-2 homolog antibody; TNRC8 antibody; Trinucleotide repeat containing 8 antibody; Vertebtate LIN2 homolog antibody
SEQUENCE SIMILARITIES
In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.; Belongs to the MAGUK family.
TISSUE SPECIFICITY
Ubiquitous. Expression is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver.
SUBCELLULAR LOCATION
Cell membrane, Cytoplasm, Membrane, Nucleus.
FUNCTION
Peripheral plasma membrane protein CASK is a protein that in humans is encoded by the CASK gene. This gene is also known by several other names: CMG 2 (CAMGUK protein 2), calcium/calmodulin-dependent serine protein kinase 3 and membrane-associated guanylate kinase 2.Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.