Lane 1: SH-SY-5Y cell lysate
Lane 2: SH-SY-5Y cell lysate with immunizaiton peptide
Applications
-
WB
-
IHC-P
-
ICC
REACTIVITY
-
Human
-
Mouse
-
Rat
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
CACNB1 Antibody (ER1803-29)
Immunogen
Synthetic peptide within rat cacnb1 aa 430-490.
Host
Rabbit
Positive Control
SH-SY-5Y, rat heart tissue, human tonsil tissue, human kidney tissue, human fetal skeletal muscle tissue, mouse brain tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Peptide affinity purified.
MOLECULAR WEIGHT
66/58/53 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB
-
1:500-1:1,000
-
IHC-P
-
1:50-1:200
-
ICC
-
1:50
TARGET
UNIPROT #
PROTEIN NAME
CACNB1
SYNONYMS
CAB1 antibody; CACB1_HUMAN antibody; CACNB1 antibody; CACNLB1 antibody; Calcium channel L type beta 1 polypeptide antibody; Calcium channel voltage dependent beta 1 subunit antibody; Calcium channel voltage-dependent subunit beta 1 antibody; CCHLB1 antibody; Dihydropyridine sensitive L type calcium channel beta 1 subunit antibody; MGC41896 antibody; Voltage dependent L type calcium channel beta 1 subunit antibody; Voltage-dependent L-type calcium channel subunit beta-1 antibody
SEQUENCE SIMILARITIES
Belongs to the calcium channel beta subunit family.
TISSUE SPECIFICITY
Detected in heart ventricle (at protein level). Isoform 1 and isoform 3 are expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Isoform 2 is expressed in skeletal muscle.
SUBCELLULAR LOCATION
Plasma membrane.
FUNCTION
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.