BOB1 Recombinant Rabbit Monoclonal Antibody [JE47-78] (ET7109-68)

UNIPROT #

Q16633

PROTEIN NAME

BOB1

SYNONYMS

B cell Oct binding protein 1 antibody;B cell specific coactivator OBF 1 antibody;B cell specific coactivator OBF1 antibody;B-cell-specific coactivator OBF-1 antibody;BOB 1 antibody;BOB-1 antibody;OBF 1 antibody;OBF1 antibody;OBF1_HUMAN antibody;OCA B antibody;OCA-B antibody;OCAB antibody;OCT binding factor 1 antibody;OCT-binding factor 1 antibody;POU class 2 associating factor 1 antibody;POU domain class 2 associating factor 1 antibody;POU domain class 2-associating factor 1 antibody;Pou2af1 antibody

SEQUENCE SIMILARITIES

Belongs to the POU2AF1 family.

TISSUE SPECIFICITY

B-cell specific.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

POU domain class 2-associating factor 1 is a protein that in humans is encoded by the POU2AF1 gene. Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers. Reduced activation of Bob1-deficient B cells following antigenic stimulation is often reported. The action of Bob1 on B cell maturation and tolerance could be mediated by effects on B cell activation, in part by regulating the expression of immunosuppressive miRNAs. Bob1 has long been considered a B cell‐specific factor that interacts with the transcription factors Oct1 and Oct2 to enhance octamer‐dependent transcription. Bob1 can directly bind to and transactivate the promoters of Bcl6 and Btla. The expression of BOB1 has proven useful for identifying certain lymphomas as being B-cell lymphomas, as exemplified in studies which use BAB1 expression to help identify lymphomas as being diffuse large B-cell lymphomas, not otherwise specified.