UNIPROT #

P41182

PROTEIN NAME

Bcl-6

SYNONYMS

B Cell Lymphoma 6 Protein antibody; B-cell CLL/lymphoma 6 antibody; B-cell lymphoma 5 protein antibody; B-cell lymphoma 6 protein transcript antibody; BCL5 antibody; BCL6A antibody; cys-his2 zinc finger transcription factor antibody; LAZ3 antibody; lymphoma-associated zinc finger gene on chromosome 3 antibody; Protein LAZ-3 antibody; ZBTB27 antibody; Zinc finger and BTB domain-containing protein 27 antibody; Zinc Finger Protein 51 antibody; zinc finger transcription factor BCL6S antibody; ZNF51 antibody

TISSUE SPECIFICITY

Expressed in germinal center T- and B-cells and in primary immature dendritic cells.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by MAPK1 in response to antigen receptor activation at Ser-333 and Ser-343. Phosphorylated by ATM in response to genotoxic stress. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.; Polyubiquitinated. Polyubiquitinated by SCF(FBXO11), leading to its degradation by the proteasome. Ubiquitinated by the SCF(FBXL17) complex, leading to its degradation by the proteaseome: ubiquitination by the SCF(FBXL17) complex takes place when aberrant BTB domain dimers are formed.; Acetylated at Lys-379 by EP300 which inhibits the interaction with NuRD complex and the transcriptional repressor function. Deacetylated by HDAC- and SIR2-dependent pathways.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Bcl-6, a transcriptional repressor, binds Stat recognition-like DNA elements and influences germinal center development and Th1/Th2 differentiation. Bcl-6 negatively regulates NFkB expression, thereby inhibiting NFkB-mediated cellular functions. HDAC- and silent information regulator (SIR)-2-dependent acet-ylation of Bcl-6 causes downregulation of activity by inhibiting the ability of Bcl-6 to recruit complexes containing histone deacetylases (HDACs). Bcl-6 is frequently deregulated in non-Hodgkin's B cell lymphomas. The human BCL6 gene has been shown to encode a protein of 706 amino acids.