Rabbit polyclonal primary
B7-H4(VTCN1) Antibody (ER1802-56)
Recombinant protein with human b7-h4 aa 50-220.
SKBR3 cell and human colon tissue lysates, MCF-7, rat epididymid tissue, human breast tissue, human breast tissue, human kidney tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein affinity purified.
31/21/10 kDa (Predicted band size)
V-set domain-containing T-cell activation inhibitor 1
B7-H4, VTCN1, B7H4
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.