Rabbit polyclonal primary
B3GAT1 Antibody (ER1901-15)
Synthetic peptide within human b3gat1 aa 30-60.
Rat brain tissue, mouse brain tissue, SH-SY5Y.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified.
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1
GlcAT-P, GlcUAT-P, B3GAT1, GLCATP
Belongs to the glycosyltransferase 43 family.
Mainly expressed in the brain.
The soluble form derives from the membrane form by proteolytic processing.
[Isoform 1]: Golgi apparatus membrane; Single-pass type II membrane protein. Secreted.; [Isoform 2]: Golgi apparatus membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane. Secreted.
Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.