Lane 1: HepG2 cell lysate
Lane 2: 293 cell lysate
Rabbit polyclonal primary
ARF1 Antibody (0807-7)
Synthetic peptide corresponding to n terminal human arf1.
HepG2 cell lysate, 293 cell lysate, 293, Hela, HepG2, human liver tissue, human colon cancer tissue, SHSY5Y.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Peptide affinity purified.
ADP Ribosylation Factor 1 antibody; ADP-ribosylation factor 1 antibody; ARF 1 antibody; ARF1 antibody; ARF1_HUMAN antibody
Belongs to the small GTPase superfamily. Arf family.
Demyristoylated by S.flexneri cysteine protease IpaJ which cleaves the peptide bond between N-myristoylated Gly-2 and Asn-3.
Cell junction, Cytoplasm, Golgi apparatus, Membrane, Synapse, Synaptosome
GTP-binding protein involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).(Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.