Lane 1: Human skeletal muscle tissue lysate
Lane 2: Rat heart tissue lysate
Rabbit polyclonal primary
Androgen Receptor Antibody (ER2001-34)
Recombinant protein within human androgen receptor aa 200-500.
Human skeletal muscle tissue lysate, rat heart tissue lysate, A549, MCF-7.
Store at +4Á¾ after thawing. Aliquot store at -20Á¾. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Androgen receptor,Dihydrotestosterone receptor,Nuclear receptor subfamily 3 group C member 4,ar
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation . Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.9 Publications Isoform 3 and isoform 4 lack the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones.