Mouse monoclonal primary
alpha Actinin Monoclonal Antibody (EM1901-52)
Synthetic peptide within human actn1 aa 350-650.
A431 cell lysates, EA.hy926, SKOV-3, human lung tissue, human liver carcinoma tissue, human skin tissue, human breast tissue, human breast carcinoma tissue, human kidney tissue, A431.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
actinin 1 smooth muscle antibody; Actinin alpha 1 antibody; actinin, alpha 1 antibody; ACTN 1 antibody; Actn1 antibody; ACTN1_HUMAN antibody; Alpha Actinin 1 antibody; Alpha actinin cytoskeletal isoform antibody; Alpha-actinin cytoskeletal isoform antibody; Alpha-actinin-1 antibody; BDPLT15 antibody; F actin cross linking protein antibody; F-actin cross-linking protein antibody; FLJ40884 antibody; FLJ54432 antibody; Non muscle alpha actinin 1 antibody; Non-muscle alpha-actinin-1 antibody
Belongs to the alpha-actinin family.
Cell membrane, cytoskeleton, Z line, cell junction, ruffle.
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.