UNIPROT #

P00352

PROTEIN NAME

ALDH1A1

SYNONYMS

Acetaldehyde dehydrogenase 1 antibody; AHD2 antibody; AL1A1_HUMAN antibody; ALDC antibody; Aldehyde dehydrogenase 1 family member A1 antibody; Aldehyde dehydrogenase 1 soluble antibody; Aldehyde dehydrogenase 1A1 antibody; Aldehyde dehydrogenase antibody; Aldehyde dehydrogenase cytosolic antibody; Aldehyde dehydrogenase family 1 member A1 antibody; Aldehyde dehydrogenase liver cytosolic antibody; ALDH 1 antibody; ALDH 1A1 antibody; ALDH class 1 antibody; ALDH, liver cytosolic antibody; ALDH-E1 antibody; ALDH1 A1 antibody; ALDH1 antibody; ALDH11 antibody; ALDH1A1 antibody; ALHDII antibody; cytosolic antibody; epididymis luminal protein 12 antibody; epididymis luminal protein 9 antibody; epididymis secretory sperm binding protein Li 53e antibody; HEL-S-53e antibody; MGC2318 antibody; PUMB1 antibody; RALDH 1 antibody; RalDH1 antibody; Retinal dehydrogenase 1 antibody

SEQUENCE SIMILARITIES

Belongs to the aldehyde dehydrogenase family.

POST-TRANSLATIONAL MODIFICATION

The N-terminus is blocked most probably by acetylation.

SUBCELLULAR LOCATION

Cytosol.

FUNCTION

The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet.