Mouse monoclonal primary
ROBO1 Monoclonal Antibody (EM1901-72)
Recombinant protein within human robo1 aa 40-300.
Siha cell lysates, SHSY5Y, Siha, human Liver cancer tissue, human kidney tissue, human stomach cancer tissue, mouse brain tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein G purified.
Predicted band size 170-181 kDa.
Roundabout homolog 1
Deleted in U twenty twenty,H-Robo-1,Roundabout homolog 1,ROBO1
Belongs to the immunoglobulin superfamily. ROBO family.
Widely expressed, with exception of kidney.
Ubiquitinated. May be deubiquitinated by USP33.
Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass membrane protein. Note=Detected at growth cones in thalamus neurons. Detected at growth cones in thalamus neurons (By similarity). PRRG4 prevents cell surface location and both colocalize in the Endoplasmic reticulum/Golgi adjacent to the cell nucleus (By similarity).
Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA. May be required for lung development (By similarity).