Location: Home >Product >Product Detail

PD-L1 [JJ08-95]

Product code:ET1701-41


  • Overview

  • Product name PD-L1
  • Molecular Wt 33 kDa
  • Description Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T cell proliferation, cytokine production, differentiation of effector T cells, and the induction of Bcl-x, a promoter of T cell survival. Conversely, engagement of CTLA4 by B7-1 or B7-2 may inhibit proliferation and IL-2 production. Pdcd-1L1 (programmed cell death ligand-1), also known as B7-H1 or PD-L1, is 290 amino acid type I transmembrane protein which is 20% and 15% identical to B7-1 and B7-2, respectively. Pdcd-1L2 has immunoglobulin V-like and C-like domains and a 30 amino acid cytoplasmic tail. It does not bind CD28, cytotoxic T-lymphocyte A4 or ICOS (inducible co-stimulator). IL-2, although produced in small amounts, is required for the effect of Pdcd-1L1 co-stimulation. The gene which encodes Pdcd-1L1 maps to human chromosome 9p24. Pdcd-1L2 (programmed cell death ligand-2) is a 73 amino acid protein which contains a signal sequence, IgV- and IgC-like domains, a transmembrane region and a cytoplasmic region. The gene which encodes Pdcd-1L2 maps to human chromosome 9p24.2. The constitutive expression of Pdcd-1L1 and Pdcd-1L2 on paren-chymal cells of heart, lung and kidney suggests that the Pdcd-1-Pdcd-L system could provide unique negative signaling to help prevent autoimmune disease.
  • Species reactivity Human, Mouse, Rat
  • Tested applications WB, IHC
  • Antibody type Recombinant Rabbit Monoclonal Antibody
  • Immunogen recombinant protein
  • Positive control

    Human tonsil tissue, mouse heart tissue, human melanoma tissue, human lung cancer tissue.

  • Conjugate Non-conjugated
  • Clone number JJ08-95
  • Alternative names B7 H antibody
    B7 H1 antibody
    B7 homolog 1 antibody
    B7-H1 antibody
    B7H antibody
    B7H1 antibody
    CD 274 antibody
    CD274 antibody
    CD274 antigen antibody
    CD274 molecule antibody
    MGC142294 antibody
    MGC142296 antibody
    OTTHUMP00000021029 antibody
    PD L1 antibody
    PD-L1 antibody
    PD1L1_HUMAN antibody
    PDCD1 ligand 1 antibody
    PDCD1L1 antibody
    PDCD1LG1 antibody
    PDL 1 antibody
    PDL1 antibody
    Programmed cell death 1 ligand 1 antibody
    Programmed death ligand 1 antibody
    RGD1566211 antibody
  • Properties

  • Form Liquid
  • Storage instructions Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Buffer 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
  • Isotype IgG
  • Purity ProA affinity purified
  • Subcellular location Cell membrane, Endomembrane system.
  • Applications

    WB: 1:1,000
    IHC: 1:50-1:200

  • Publishing research using PD-L1? Please let us know so that we can cite the reference in this datasheet.

  • Data sorting...

Choose your product,application and species below,then click "Create".

On the next page you can complete and submit your review.

  • * Code.NO
  • * Application
  • *Sample
  • Species Tested
  • Against
  • Choose text
  • Content

Leave us a review

Specific Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Submission...